using multiple wordlists

[mbox mbarsalou]

I was thinking about using multiple word lists and was looking for
advice.

I thought maybe I would use a system based wordlist and a user based
wordlist.  The idea would be to have the system one remove a majority of
the SPAM as well as train it to catch viruses.

Then leave the user based one to manage the needs of the individual
user.

Has anyone implemented something like this and are there some reasonably
good instructions on how to set this up?  

Thanks for any help.

BTW, I love using bogofilter.

Mike B.